The Lopchuk lab @ Moffitt Cancer Center

Our research program is grounded in synthetic organic chemistry with a specific focus on the development of new reactions, the design of new reagents, and the total synthesis of natural products with anti-cancer activity. We also have a variety of medicinal chemistry collaborations with other groups at Moffitt. Take a look at the different types of research we have ongoing and some of our recent publications. If you are interested in joining the group, see what positions we have available.

NEWS!

10/25/19 – Our annual review of the synthesis and reactivity of pyrroles, indoles, and related heterocycles in Progress in Heterocyclic Chemistry, Vol. 31 is now available.

10/15/19 – Four new graduate students from the USF Department of Chemistry have joined the group. Welcome to Khalilia Tillett, Kyle Pedretty, Brooke Vitale, and William Tsuei! Khalilia, Kyle, and Brooke will be working on various methodology projects, while William will be focused on the total synthesis of complex natural products.

8/5/19 – A new postdoctoral fellow has joined the group! Welcome to Zac Shultz, who received his Ph.D. from the University of South Florida while working in the group of Prof. James Leahy. Zac will be developing small molecule inhibitors via structure-based drug design.

5/31/19 – Our book chapter reviewing the isolation, biological activity, and synthesis of imide-containing natural products is now available.

3/18/19 – A new postdoctoral fellow has joined the group! Welcome to Wen Che, who received his Ph.D. from Nankai University, State Key Laboratory of Elemento-organic Chemistry while working in the group of Prof. Qi-Lin Zhou. Wen will be developing scalable syntheses of complex withanolide natural products.

1/10/19 – A new graduate student has joined the group! Welcome to Vishala Maharaj, who received her B.S. from the University of the West Indies, Cave Hill. After gaining experence in the synthesis of fused indoles in the lab of Prof. Jeanese Badenock, Vishala will be working on the development and application of new strained amination regents.

11/2/18 – A new postdoctoral fellow has joined the group! Welcome to Thomas Scattolin, who received his Ph.D. from RWTH Aachen University while working in the group of Prof. Franziska Schoenebeck.

11/1/18 – Our annual review of the synthesis and reactivity of pyrroles, indoles, and related heterocycles in Progress in Heterocyclic Chemistry, Vol. 30 is now available.

9/1/18Now Recruiting! We are currently accepting graduate students from the Department of Chemistry @ USF. Students will receive a thorough training in synthetic organic chemistry (methodology and/or total synthesis) with the option of learning about medicinal chemistry, rational drug design, and translational research in cancer drug discovery.

4/24/18 – Our new method for the gram-scale synthesis of 3-haloazetidines via strain-release chemistry has been published. Congrats Youngran!

9/18/17Now Recruiting! We are currently accepting graduate students from the Department of Chemistry @ USF. Students will receive a thorough training in synthetic organic chemistry (methodology and/or total synthesis) with the option of learning about medicinal chemistry, rational drug design, and translational research in cancer drug discovery.

9/12/17 – Our annual review of the synthesis and reactivity of pyrroles, indoles, and related heterocycles in Progress in Heterocyclic Chemistry, Vol. 29 is now available. Work on next year's contribution is already underway!

9/5/17 – Interested in Strain-Release Functionalization? Three new e-EROS articles are now available on [1.1.1]propellane, 1-aza[1.1.0]bicyclobutane, and 1-((3,5-difluorophenyl)sulfonyl)bicyclo[1.1.0]butane.