The Lopchuk lab @ Moffitt Cancer Center

Our research program is grounded in synthetic organic chemistry with a specific focus on the development of new reactions, the design of new reagents, and the total synthesis of natural products with anti-cancer activity. In collaboration with other research groups at Moffitt, we will apply our chemistry to synthesize chemical probes designed to interrogate the function of key oncoproteins and immune-regulatory proteins, while ultimately seeking to develop these probes and lead compounds into novel anti-cancer drugs.


4/24/18 – Our new method for the gram-scale synthesis of 3-haloazetidines via strain-release chemistry has been published. Congrats Youngran!

9/18/17Now Recruiting! We are currently accepting graduate students from the Department of Chemistry @ USF. Students will receive a thorough training in synthetic organic chemistry (methodology and/or total synthesis) with the option of learning about medicinal chemistry, rational drug design, and translational research in cancer drug discovery.

9/12/17 – Our annual review of the synthesis and reactivity of pyrroles, indoles, and related heterocycles in Progress in Heterocyclic Chemistry, Vol. 29 is now available. Work on next year's contribution is already underway!

9/5/17 – Interested in Strain-Release Functionalization? Three new e-EROS articles are now available on [1.1.1]propellane, 1-aza[1.1.0]bicyclobutane, and 1-((3,5-difluorophenyl)sulfonyl)bicyclo[1.1.0]butane.