Independent Career.

Coming soon...


Before Moffitt.

16. Lopchuk, J. M.; Fjelbye, K.; Kawamata, Y.; Malins, L. R.; Pan, C.-M.; Gianatassio, R.; Wang, J.; Prieto, L.; Bradow, J.; Brandt, T. A.; Collins, M. R.; Elleraas, J.; Ewanicki, J.; Farrell, W.; Fadeyi, O. O.; Gallego, G. M.; Mousseau, J. J.; Oliver, R.; Sach, N. W.; Smith, J. K.; Spangler, J. E.; Zhu, H.; Zhu, J.; Baran, P. S. Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity. J. Am. Chem. Soc. 2017, 139, 3209-3226.
     – Highlighted in Synfacts 2017, 13, 463, by V. Snieckus and P. Mukherjee.

 
 

15. Gianatassio, R.*; Lopchuk, J. M.*; Wang, J.; Pan, C.-M.; Malins, L. R.; Prieto, L.; Brandt, T. A.; Collins, M. R.; Gallego, G. M.; Sach, N. W.; Spangler, J. E.; Zhu, H.; Zhu, J.; Baran, P. S. Strain-Release Amination. Science 2016, 351, 241–246.
     – Covered as “News of the Week” in C&E News 2016, 94, 5–6 & Highlighted in RSC’s Chemistry World.
     – Highlighted in Nature Chemistry 2016, 8, 296–297, by J. A. Milligan and P. Wipf.
     – Highlighted in Synfacts 2016, 12, 352, by V. Snieckus and J.I. Trujillo.
     – Highlighted in The Medicine Maker 2016, 0216-202, under the title "Suspended Amination".

 
 

14. Cherney, E. C.; Lopchuk, J. M.; Green, J. C.; Baran, P. S. A Unified Approach to ent-Atisane Diterpenes and Related Alkaloids: Synthesis of (–)-Methyl Atisenoate, (–)-Isoatisine, and the Hetidine Skeleton. J. Am. Chem. Soc. 2014, 136, 12592–12595.
     – Highlighted in Synfacts 2014, 10, 1120, by E.M. Carreira and H.F. Zipfel.

 
 

13. Montgomery, W. L.; Lopchuk, J. M.; Gribble, G. W.; Jasinski, J. P. Synthesis, crystal structures and DFT calculations of three new cyano(phenylsulfonyl)indoles and a key synthetic precursor compound. Crystals 2015, 5, 376–393.

12. Lopchuk, J. M.; Song, M.; Butler, B.; Gribble, G. W. Synthesis of heteroaryl-substituted pyrroles via the 1,3-dipolar cycloaddition of unsymmetrical münchnones and nitrovinyl heterocycles, Synthesis 2015, 47, 2776–2780.
     – Invited contribution for thematic issue: Cycloaddition Reactions and Methods.
     – Selected by the editorial board for the cover of issue 18/2015.

11. Lopchuk, J. M.; Gribble, G. W. Total synthesis of atorvastatin via a late-state, regioselective 1,3-dipolar münchnone cycloaddition. Tetrahedron Lett. 2015, 56, 3208–3211.
     – Invited contribution for Symposium in print: In Memory of Harry Wasserman.

10. Lopchuk, J. M.; Gribble, G. W. The reaction of arynes with münchnones: synthesis of isoindoles and azaisoindoles. Tetrahedron Lett. 2014, 55, 2809–2812.

9. Lopchuk, J. M.; Gribble, G. W.; Jasinski, J. P. Methyl 1-benzyl-5-methyl-2,4-diphenyl-1H-pyrrole-3-carboxylate. Acta Cryst. 2014, E70, o338.

8. Lopchuk, J. M.; Hughes, R. P.; Gribble, G. W. What controls regiochemistry in 1,3-dipolar cycloadditions of münchnones with nitrostyrenes? Org. Lett. 2013, 15, 5218–5221.

7. Lopchuk, J. M.; Montgomery, W.; Jasinski, J. P.; Gorjifard, S.; Gribble, G. W. Manganese(III)-mediated oxidative radical addition of malonates to 2-cyanoindole. Tetrahedron Lett. 2013, 54, 6142–6145.

6. Lopchuk, J. M.; Green, I. L.; Badenock, J. C.; Gribble, G. W. A short, protecting group-free total synthesis of bruceollines D, E, and J. Org. Lett. 2013, 15, 4485–4487.

5. Lopchuk, J. M.; Gribble, G. W.; Jasinski, J. P. Bruceolline D: 3,3-dimethyl-1H,4H-cyclopenta[b]indol-2(3H)-one. Acta Cryst. 2013, E69, o1043.

4. Lopchuk, J. M.; Gribble, G. W.; Millikan, S. P.; Jasinski, J. P. Bruceolline J: 2-Hydroxy-3,3-dimethyl-2,3-dihydrocyclopenta[b]indol-1(4H)-one. Acta Cryst. 2013, E69, o1351–o1352.

3. Lopchuk, J. M.; Gribble, G. W. A convenient 1,3-dipolar cycloaddition approach to pyridylpyrroles. Tetrahedron Lett. 2011, 52, 4106–4108.
     – Highlighted in Synfacts 2011, 10, 1054, by V. Snieckus and M. O. Kitching.

2. Lopchuk, J. M.; Gribble, G. W. Synthesis of 2- and 3-indolylpyrroles via 1,3-dipolar cycloadditions of münchnones and nitroalkenes. Heterocycles 2011, 82, 1617–1631.
     – Special issue dedicated to Professor Albert Eschenmoser on the occasion of his 85th birthday.

1. Sporn, M. B.; Liby, K. T.; Yore, M. M.; Fu, L.; Lopchuk, J. M.; Gribble, G. W. New synthetic triterpenoids: Potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress. J. Nat. Prod. 2011, 74, 537–545.


patents

1. Gribble, G. W.; Lopchuk, J. M. Compositions and methods for treating cancer. U.S. Patent Application, 20120022097, September 20, 2011; US Patent 8,975,274 issued March 10, 2015.


book chapters

8. Lopchuk, J. M. Pyrroles and Benzo Derivatives. In Progress in Heterocyclic Chemistry, Gribble, G. W.; Joule, J. A., Eds.; Elsevier Science: New York, 2016, 28, 165–218.

7. Gianatassio, R.; Lopchuk, J. M.* Pyrroles and Benzo Derivatives. In Progress in Heterocyclic Chemistry, Gribble, G. W.; Joule, J. A., Eds.; Elsevier Science: New York, 2015, 27, 159–202.

6. Lopchuk, J. M. Pyrroles and Benzo Derivatives. In Progress in Heterocyclic Chemistry, Gribble, G. W.; Joule, J. A., Eds.; Elsevier Science: New York, 2014, 26, 151–192.

5. Lopchuk, J. M. Pyrroles and Benzo Derivatives. In Progress in Heterocyclic Chemistry, Gribble, G. W.; Joule, J. A., Eds.; Elsevier Science: New York, 2013, 25, 137–182.

4. Lopchuk, J. M. Pyrroles and Benzo Derivatives. In Progress in Heterocyclic Chemistry, Gribble, G. W.; Joule, J. A., Eds.; Elsevier Science: New York, 2012, 24, 169–204.

3. Lopchuk, J. M. Mesoionics. In Topics in Heterocyclic Chemistry. Gribble G.W., Ed.; Metalation of Azoles and Related Five-Membered Ring Heterocycles; Springer-Verlag: Berlin, 2012, 29, 381–413.

2. Lopchuk, J. M. Azoles with 3-4 Heteroatoms. In Topics in Heterocyclic Chemistry. Gribble G.W., Ed.; Metalation of Azoles and Related Five-Membered Ring Heterocycles; Springer-Verlag: Berlin, 2012, 29, 415–440.

1. Lopchuk, J. M. Recent advances in the synthesis of Aspidosperma-type alkaloids. In Progress in Heterocyclic Chemistry, Gribble, G. W.; Joule, J. A., Eds.; Elsevier Science: New York, 2011, 23, 1–25.